pulv. capsici gr. j to ij, were added with success. of cases, it was given in solution. R.-Cinchoniæ gr. xx; Spt. æth. nit., Syr. simplicis, aa 3ss; Ol. limon. gtt. j to ij. In a majority Sig. Give one to two teaspoonfuls every two hours. From ten to fifteen grains were given in the form of pill or solution on the seventh, fourteenth, and twenty first days after the last paroxysm. As a tonic, one to two grains were given every three to six hours, to promote digestion, give tone to and invigorate the system. For anæmia and neuralgia, it was combined with Vallet's mass, tr. ferri chlor., vegetable extracts, &c. For anæmia and debility R.-Pil. ferri carb. gr. xx; Cinchoniæ gr. xv ; Ext. hyos. gr. vj.—M. Ft. pil. no. xx. Sig. One every three hours. For neuralgia, the result of anæmia R.-Cinchoniæ gr. xx; Tr. ferri chlor., Tr. cinnam. comp., aa 3ss. Sig.-Five, ten, to twenty drops every two to four hours in water. In sciatica R.-Cinchoniæ gr. xx; Chloroform 3ss; Glycerine 3j; Morph. sulph. gr. j. Sig. Half a teaspoonful every four hours. In cases of nervousness and hysteria For neuralgia in the supra-orbital nerves, &c. 154 USE OF CINCHONIA IN MALARIOUS DISEASES. The following table will show the number of ounces prescribed during each year: Dr. Wm. Pepper, in an article published in the Amer. Journal of Med. Sciences, Jan., 1857, on his experience in the use of the sulphate of cinchonia, states that he has used it in fifteen cases with the most signal success in the treatment of intermittent fevers, &c. Dr. Kenderdine, the resident physician in the Hospital of the Protestant Episcopal Church in Philada., also states, in a communication dated Oct. 7th, 1854, addressed to Powers & Weightman, that he has used the sulphate in over three hundred cases of malarious fevers of various types successfully. The experience of the physi cians quoted above prove conclusively that the sulphate of cinchonia is a remedy for intermittent fevers, fully as efficacious as the sulphate of quinia. My experience in its use fully confirms the evidence given above. I can fully recommend the use of the pure alkaloid cinchonia in all periodical diseases, neuralgic affections, and debility following acute diseases, it proving, in my experience, quite as efficacious as quinia, and, in many cases, more prompt. I have preferred the pure cinchonia to the sulphate, owing to the latter being more nauscous, and less acceptable to the stomach. I think that the evidence I have had of the efficacy of the pure alkaloid justifies me in believing it equal, if not superior, to quinia, and I feel confident that the profession will sustain the evidence given of its efficacy after giving it a fair and impartial trial. Respectfully submitted by F. HINKLE. REPORT ON THE BLENDING AND CONVERSION OF TYPES IN FEVER. No disease, since medicine became a science, has demanded, or received so much attention as fever, and, perhaps, there is no one upon which, at the present time, so great a diversity of opinion is held by the profession. This diversity pertains alike to the cause, essential nature, and just treatment of the disease. This difference of opinion is, perhaps, mainly owing to our inability, or rather the impossibility, of presenting any definition sufficiently exact and comprehensive to suit such an infinite variety of forms; and so long as our knowledge of the essential nature of this disease is as limited as it is to-day, it will be equally impossible to obtain any single description implicating all its varieties. Since all are agreed as touching the main features of this disease, which features are present more or less in all its forms, I infer that there is some one essential condition or state of the system, forming a common point of departure for all its varieties. It is this condition in which Holland finds the bond by which to associate together numerous forms of disease, and which Paine declares to be the general pathological cause of all fevers. This is that primordial condition, without the existence and presence of which, whatever may be the affection of the system, it cannot be called fever. What is the essential nature of this condition or state, and how far it is modified by the full development and continuance of thẻ disease, may not be satisfactorily known. Virchow says, "Fever consists essentially in elevation of temperature, which must arise from increased tissue change." Dr. Stokes regards it "a condition of minus vitality;" Sir James Murray, " a disturbed electrical state." Whether the truth lies in either or all these opinions, or in some direction not yet conceived of, our present knowledge does not determine. It is evident, the phenomena which characterize the different forms of the disease, must depend upon the character of |