Modified-Release Drug Delivery TechnologyMichael J. Rathbone, Jonathan Hadgraft, Michael S. Roberts CRC Press, 7 Nov 2002 - 1032 halaman Describing formulation challenges and their solutions in the design, development, and commercialization of modified-release drugs delivery systems, this book contains eighty papers that review recent developments in design and manufacturing techniques. It includes detailed descriptions of extended release drug products for the oral, nasal, ophthalmic, pulmonary, vaginal, dermal and transdermal pathways. With the exception of the final section addressing regulatory issues, each section covers a particular route for drug delivery and opens with an overview of the anatomical, physiological, and pharmaceutical basics of each route before moving on to cover specific technologies. |
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Modified-Release Drug Delivery Technology Michael J. Rathbone,Jonathan Hadgraft,Michael S. Roberts Pratinjau tidak tersedia - 2002 |
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absorption acid active administration aerosol agents ALZA Corporation application aqueous betaxolol bioadhesive bioavailability buccal cavity chitosan clinical coating colon concentration Control Rel controlled release controlled-release core delivered device diltiazem dispersion dissolution dosage form dose drug delivery systems drug release dry powder E-TRANS effect efficacy enhancers estradiol evaluation excipients fentanyl Figure fluid formulation gelatin capsules human hydrophilic implant injection insulin Int J Pharm Intraject layer leuprolide lipid liposomes liquid lung manufacturing matrix Medipad membrane method microneedles microspheres modified-release mucoadhesive mucosa nanoparticles nasal nifedipine ocular ophthalmic oral osmotic particles patients penetration peptides PerioChip permeability Pharm Res Pharm Sci pharmaceutical pharmacokinetic Pharmacol phase phospholipid plasma PLGA polymer protein pulmonary regulatory release profile release rate respiratory skin solid solubility solution solvent spray stability stratum corneum studies surface suspension tablet testing therapeutic therapy tion tissue transdermal Transfersome treatment vaginal vitro vivo Zydis