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Mob.

TREASURY DEPARTMENT
Public Health and Marine-Hospital Service of the United States

PUBLIC HEALTH BULLETIN No. 47

SEPTEMBER, 1911

STUDIES UPON LEPROSY

i XIV. THE ARTIFICAL CULTIVATION OF THE BACILLUS

OF LEPROSY

XV. ATTEMPTS AT SPECIFIC THERAPY IN LEPROSY

BY

DONALD H. CURRIE

PASSED ASSISTANT SURGEON AND DIRECTOR LEPROSY INVESTIGATION STATION

MOSES T. CLEGG

ASSISTANT DIRECTOR LEPROSY INVESTIGATION STATION

AND

HARRY T. HOLLMANN

ACTING ASSISTANT SURGEON LEPROSY INVESTIGATION STATION

Investigations made in accordance with
the Act of Congress approved

March 3, 1905

WASHINGTON
GOVERNMENT PRINTING OFFICE

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By DONALD H. CUBRIE,
Passed Assistant Surgeon and Director Leprosy Inrestigation Station;

MOSES T. CLEGG,
Assistant Director Leprosy Investigation Station;

and

H. T. HOLLMANN,
Acting Assistant Surgeon Leprosy incestigation Station,

INTRODUCTION.

The greatest obstacle that has been met with in the past investigations of leprosy has been our inability to artificially propagate the bacillus, either on culture media or in laboratory animals.

Without this knowledge studies in specific therapy were at least difficult, if not quite impossible; and studies in transmission were limited chiefly to clinical observations, or to the mere recording of the findings of lepra bacilli in certain tissues or discharges of lepers or insects or objects that had come into contact with lepers. If the results which we record here are confirmed by others and become generally accepted, there should result a renewed interest in this dis ease in both leprous and nonleprous countries, and such internt may possibly result in the acquisition of knowledge that will be of us in the control of this disease.

REVIEW OF LITERATURE.

Bacterial rods were first described as being present in a la prota by Hansen (1) in 1868 and 1873, and by Vandeycke Carter (1): three observations were soon afterwards confirmed by Klebs (1). Auspitz (1), Daniellsen (1), and Neisser (1). From that time up to the press ent numerous attempts have been made, as the below-gisen literature will indicate, to cultivate this organism on artificial media: but up to 1909, when Clegg (52) was successful in repeatedly growing arada fast bacilli, morphologically identical with the organiem found in

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