Microbial Production of Biopolymers and Polymer Precursors: Applications and Perspectives
A huge variety of biopolymers - such as polysaccharides, polyesters, and polyamides - are naturally produced by microorganisms. These range from viscous solutions to plastics. Their physical properties are dependent on the composition and molecular weight of the polymer. The genetic manipulation of microorganisms opens up an enormous potential for the biotechnological production of biopolymers with tailored properties suitable for high-value medical application such as tissue engineering and drug delivery. Written by expert, internationally renowned scientists, this comprehensive volume describes in detail the use of microorganisms for the production of the most important biopolymers and polymer precursors. The contributors describe in depth the biosynthetic pathways, physical properties, and industrial production processes; and they discuss in detail the genetic and metabolic engineering of microorganisms for biopolymer production. Also highlighted are the applications and potential applications of the biopolymers and microbial biotechnology. Topics include the biochemistry and genetics of biosynthesis of xanthan, alginate, cellulose, cyanophycin, poly(gamma-glutamic acid), levan, hyaluronic acid, organic acids, oligosaccharides and polysaccharides, and polyhydroxyalkanoates. This book is recommended book for all biotechnology and microbiology laboratories.
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Acetobacter Acetobacter xylinum acetylation acid production activity alginate alginate biosynthesis alginate lyase amino acid anthracis Appl applications Ashiuchi ATCC Bacillus licheniformis Bacillus subtilis bacterial cellulose Bacteriol bcsA binding Biochem biodegradable Biol biopolymer Biosci biosynthesis Biotechnol campestris carbohydrate carbon source cell cellulose cellulose biosynthesis cellulose synthase chain charide Chem chemical cloning complex CphA culture cyanophycin degradation encoding enzyme Escherichia coli exopolysaccharide extracellular fermentation formation fumaric acid function gene genetic genome glucose glutamic acid glycosyltransferases host industrial involved l-glutamic lactic acid levan licheniformis medium membrane metabolic engineering microbial Microbiol microorganisms molecular weight monomers mutants Ohman oligosaccharide oligosaccharide synthesis operon organism pathway periplasmic PHA granules PHA synthase polymer polymerization polysaccharide precursor properties protein Pseudomonas aeruginosa recombinant regulation Rehm residues role sequence Steinbüchel strain structure studies substrate succinic acid sugar nucleotide synthetase tion UDP-glucose vinelandii vitro xanthan gum Xanthomonas xylinus