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No. 191. WEED, LEWIS H. A Reconstruction of the Nuclear Masses in the Lower Portions of the Human Brain-Stem. (Contribution to Embryology.) Quarto, 78 pages, vi plates. Published 1914. Price $2.50.

This comprises a study of the form and relations of the collections of ganglion cells making up the nuclei of the upper cervical cord and medulla of the adult human brain. It is a description of a model made by reconstructing, in wax, a series of 1900 cross-sections, 40μ thick, taken through a normal human brain stem, treated by the Weigert-Pal method. This model is illustrated from the dorsal, lateral, and ventral aspects, and embraces a special morphological study of the nucleus olivaris inferior. The conformation of each nuclear mass is described in its relation to the surface and to the surrounding structures.

No. 221. Mall, Franklin P. On the Fate of the Human Embryo in Tubal Pregnancy. (Contribution to Embryology, No. 1.. Vol. I.) Quarto, 104 pages, 11 plates, 24 text figures. Published 1915. Price $5.00.

This monograph on the fate of the human ovum in tubal pregnancy is based on the study of 146 specimens which have been collected by about 100 physicians in various parts of the United States and Asia during the past 18 years. The scope of the work is not only embryological but etiological-that is, the cause of tubal pregnancy receives due consideration. The anatomy of the Fallopian tube is first considered, after which there is a discussion of normal specimens which are found implanted in the tube. Pathological embryos, which are frequently encountered, are discussed, and pathological ova without embryos are also considered. The facts observed support the theory of an inflammatory causation. In about 90 per cent of the cases it is found that the embryo is also diseased or arrested in development.

No. 222. Contributions to Embryology, Nos. 2, 3, 4, 5, and 6. Vol. II. Quarto, 108 pages. Published 1915. Price $3.00.

This book contains the following papers, not sold separately:

WATT, JAMES C.-Description of Two Young Twin Human Embryos with 17-19
paired Somites. (Contribution No. 2.) 39 pages, 4 plates, 7 figs.

CLARK, ELIOT R.-An Anomaly of the Thoracic Duct with a bearing on the
Embryology of the Lymphatic System. (Contribution No. 3.) 10 pages, 3 figs.
MEYER, A. W.-Fields, Graphs, and other Data on Fetal Growth. (Contribu
tion No. 4.) 14 pages, 13 figs.

CORNER, GEORGE W.-The Corpus Luteum of Pregnancy, as it is in Swine. (Con-
tribution No. 5.) 24 pages, 3 plates.

ESSICK, CHARLES R.-Transitory Cavities in the Corpus Striatum of the Human
Embryo. (Contribution No. 6.) 14 pages, 3 plates.

No. 223. Contributions to Embryology, Nos. 7, 8, and 9. Vol. III. Quarto, 90 pages. Published 1915. Price $5.00.

This book contains the following papers, not sold separately:

SABIN, FLORENCE R.-On the Fate of the Posterior Cardinal Veins and their
relation to the Development of the Vena Cava and Azygos in the Embryo
Pig. (Contribution No. 7.) 32 pages, 7 plates.

DUESBERG, J.-Recherches Cytologiques sur la Fécondation des Ascidiens et sur
leur Développement. (Contribution No. 8.) 38 pages, 3 plates.

SHIPLEY, PAUL G., and GEORGE B. WISLOCKI.-The Histology of the Poison Glands
of Bufo aqua and its bearing upon the formation of Epinephrin within the
Glands. (Contribution No. 9.) 20 pages, 2 plates.

No. 224. Contributions to Embryology, Nos. 10, 11, 12, and 13. Vol. IV. Quarto, 106 pages. Published 1916. Price $3.00.

This book contains the following papers, not sold separately:

MALL, F. P.-The Human Magma Réticulé in Normal and in Pathological
Development. (Contribution No. 10.) 22 pages, 3 plates.

COWDRY, E. V.-The Structure of Chromophile Cells of the Nervous System.
(Contribution No. 11.) 18 pages, I plate.

CUNNINGHAM, R. S.-On the Development of the Lymphatics of the Lungs in
the Embryo Pig. (Contribution No. 12.) 24 pages, 5 plates.

MACKLIN, CHARLES C.-Binucleate Cells in Tissue Cultures. (Contribution No. 13.)
38 pages, 70 figs.

No. 225. WEED, LEWIS H. Development of the Cerebro-spinal Spaces. (Contribution to Embryology, No. 14. Vol. V.) 116 pages, 17 plates. Published 1917. Price $6.00.

This represents the results of a study of the formation of the pathways for the cerebro-spinal fluid in two mammalian embryos. Data regarding the stages in the initial spread of this fluid were obtained by morphological studies and by a physiological method of replacement of the existent fluid. Two functional areas for the extraventricular passage of the embryonic ventricular fluid are described. The process of differentiation of the perimedullary mesenchyme into the three meninges of the adult is considered with regard especially for the circulation of the cerebro-spinal fluid through the subarachnoid spaces. Throughout this paper, the morphological changes in the development of the cerebro-spinal spaces have been related as far as possible to the physiological use of these channels.

No. 226. Contributions to Embryology, Nos. 15, 16, 17, 18, 19. Vol. VI. Quarto, 168 pages. Published 1917. Price $7.00.

This book contains the following papers, not sold separately:

MALL, FRANKLIN P.-Cyclopia in the Human Embryo. (Contribution No. 15.)
29 pages, 3 plates, 8 figs.

THURLOW, MADGE DEG.-Quantitative Studies on Mitochondria in Nerve Cells.
(Contribution No. 16.) 10 pages, I plate.

LEWIS, MARGARET REED.-The Development of Connective Tissue Fibers in Tissue
Culture of Chick Embryos. (Contribution No. 17.) 16 pages, 2 plates.
SABIN, FLORENCE R.-Origin and Development of the Primitive Vessels of the
Chick and of the Pig. (Contribution No. 18.) 64 pages, 7 plates, 8 figs.
JOHNSON, FRANKLIN PARADISE.-A Human Embryo of Twenty-four pairs of Somites.
(Contribution No. 19.) 42 pages, 8 plates, 9 figs.

No. 227. Contributions to Embryology, Nos. 20, 21, 22, and 23. Vol. VII. Quarto, 136 pages. Published 1918. Price $4.00.

This book contains the following papers, not sold separately:

STREETER, GEORGE L.-The Histogenesis and Growth of the Otic Capsule and its
Contained Periotic Tissue-spaces in the Human Embryo. (Contribution No. 20.)
50 pages, 4 text figs. and 4 plates.

VAN DER STRICHT, O.-The Genesis and Structure of the Membrana Tectoria and
the Crista Spiralis of the Cochlea. (Contribution No 21.) 32 pages, 4 plates.
WHEELER, THEODORA.-Study of a Human Spina Bifida Monster with Encephaloceles
and other Abnormalities. (Contribution No. 22.) 23 pages, 4 plates.
INGALLS, N. W.-A Human Embryo before the Appearance of the Myotome. (Con-
tribution No. 23.) 24 pages, 5 text figs. and 4 plates.

No. 271. Contributions to Embryology, Nos. 24, 25, 26. Vol. VIII. Quarto, 198 pages. Published 1918. Price $5.50.

This book contains the following papers, not sold separately:

STREETER, GEORGE L.-The Developmental Alterations in the Vascular System of the
Brain of the Human Embryo. (Contribution No. 24.) 38 pp., 5 pls., 12 text figs.
COWDRY, E. V.-The Mitochondrial Constituents of Protoplasm. (Contribution No.
25.) 120 pages, I plate, 9 figs.

KUNITOMO, KANAE.-The Development and Reduction of the Tail and the Caudal
End of the Spinal Cord. (Contribution No. 26.) 38 pages, 4 plates, 2 text figs.

No. 272. Contributions to Embryology, Nos. 27 to 46. Vol. IX. Quarto. In press.
This book contains the following papers:

MACKLIN, CHARLES C.-The Development and Function of Macrophages in the Repair
of Experimental Bone-Wounds in Rats vitally stained with Trypan-Blue. (Con-
tribution No. 27.) 32 pages, 4 plates.

DUESBERG, J.-Cytoplasmic Structures in the Seminal Epithelium of the Opossum.
(Contribution No. 28.) 35 pages, 2 plates, 5 text figs.

CORNER, GEORGE W.-On the Widespread Occurrence of the Reticular Fibrils pro-
duced by Capillary Endothelium. (Contribution No. 29.) 8 pages, 2 plates.
WHEELER, THEODORA. Variability in the Spinal Column as regards Defective
Neural Arches. (Rudimentary Spina Bifida.) (Contribution No. 30.) 12 pages,
II figures.
VAN DER STRICHT, O.-The Arrangement and Structure of Sustentacular Cells and
Hair Cells in the Developing Organ of Corti. (Contribution No. 31.) 33
pages, 4 plates.
RETZER, ROBERT.-The Sino-ventricular Bundle. A Functional Interpretation of
Morphological_Findings. (Contribution No. 32.) 13 pages, I plate.
JENKINS, GEORGE B.-A Study of the Superior Olive. (Contribution No. 33.) 15
pages, 2 pls., I text fig.

SCHULTZ, ADOLPH H.-The Development of the External Nose in Whites and
Negroes. (Contribution No. 34.) 17 pages, I plate, 7 figs.

LEWIS, MARGARET REED.-Muscular Contraction in Tissue Cultures.
No. 35.) 25 pages, 2 plates, 6 text figs.

(Contribution

SABIN, FLORENCE R. Studies on the Origin of Blood-vessels and of Red-Blood-Cor-
puscles as seen in the Living Blastoderm of Chicks during the Second Day of
Incubation. (Contribution No. 36.) 49 pages, 6 pls., I text fig.

BEAN, ROBERT BENNETT.-Notes on the Postnatal Growth of the Heart, Kidneys,
Liver, and Spleen in Man. (Contribution No. 37.) 21 pages, 8 text figs.
MILLER, WILLIAM SNOW.-A Morphological Study of the Tracheal and Bronchial
Cartilages. (Contribution No. 38.) 39 pages, 25 figs.

LEWIS, WARREN H.-The Cartilaginous Skull of a Human Embryo 21 millimeters
in length. (Contribution No. 39.) 39 pages, 6 pls., 16 figs.

MEYER, ARTHUR WILLIAM.-Hydatiform Degeneration in Tubal and Uterine Preg-
nancy. (Contribution No. 40.) 21 pages, 6 plates.

MEYERS, BURTON D.-A Study of the Development of Certain Features of the
Cerebellum. (Contribution No. 41.) 23 pages, 6 figures.

ESSICK, CHARLES R.-Formation of Macrophages by the Cells lining the Subarach-
noid Cavity in response to the Stimulus of Particulate Matter. (Contribution

No. 42.) 12 pages, I pl.

STREETER, GEORGE L.-A Human Embryo (Mateer) of the Presomite Period.
(Contribution No. 43.) 35 pages, 6 pls., 4 text figs.

WEED, LEWIS H.-The Experimental Production of an Internal Hydrocephalus.
(Contribution No. 44.) 22 pages, 2 plates.

CLARK, ELIOT R., and ELEANOR LINTON CLARK.-On the Origin and Early De-
velopment of the Lymphatic System of the Chick. (Contribution No. 45.)
36 pages, 7 plates, 15 text figures.

BARDEEN, C. R.-The Height-weight Index in relation to Linear and Volumetric
Proportions of the Body during Postnatal Development. (Contribution No.
46.) 72 pages, 11 charts, 2 text figures.

Publication 272 will constitute a memorial volume to Dr. Mall.

No. 273. Contributions to Embryology, No. 47. Vol. X. Quarto. In press.
This book contains the following papers, not sold separately:

EVANS, HERBERT MCLEAN and KATHARINE J. SCOTT.-On the Differential Reaction
to Vital Dyes of the Two Great Groups of Connective Tissue Cells. (Contribu-
tion No. 47.)

No. 274. Contributions to Embryology, Nos. 49, 50, 51, 52. Vol. XI. Quarto. In press.

This book contains the following papers, not sold separately:

DANCHAKOFF, VERA.-Myeloid Metaplasia of the Embryonic Mesenchyme in rela-
tion to Cell Potentialities and Differential Factors. (Contribution No. 49.)
LINEBACK, PAUL E.-Studies on the Longitudinal Muscle of the Human Colon,
with Special Reference to the Development of the Tæniæ. (Contribution
No. 50.)
WISLOCKI, GEORGE B.-Experimental Studies on Fetal Absorption. I: The Vitally
Stained Fetus. (Contribution No. 51.)
INGALLS, N. WILLIAM.-A Human Embryo at the beginning of Segmentation, with
Special Reference to the Vascular System. (Contribution No. 52.) 5 plates,
1 text figure.

A MONTHLY CLASSIFIED RECORD OF THE CURRENT MEDICAL LITERATURE OF

THE WORLD.

The Index Medicus was established in 1879, under the editorship of Dr. John S. Billings and Dr. Robert Fletcher, and was discontinued in 1899. The volumes of this first series are now out of print. The Carnegie Institution of Washington began the printing of the second series with the number of January 1903. Each number presents the literature of the month named on its cover and is issued as early as possible in the succeeding month, time being allowed for the arrival of foreign journals. The editor is Fielding H. Garrison, M.D.

This publication consists of the titles in full of books, pamphlets, theses, contributions to co-operative works and original articles in journals, transactions of medical and scientific societies, and the like, arranged under subject-headings. The titles in certain languages, as Russian, Polish, Swedish, Danish, Finnish, Hungarian, Bohemian, Roumanian, and Japanese, are translated into English. A table of contents accompanies each number, and a few months after the completion of each volume an "Annual Index of Authors and Subjects" is issued. The subject part of this annual index is elaborately subdivided, the classification resembling that of the Index Catalogue of the Library of the Surgeon General's Office, U. S. Army. Of the second series Vols. I-VI (1903-1908) are available at the original rate of $5.00 a volume, with 60 cents additional for postage when sent to foreign countries; Vols. VII to XVII at the present rate, as follows:

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Remittances should be made by money order or New York exchange. All communications should be addressed

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No. 42. ATWATER, W. O., and F. G. BENEDICT. A Respiration Calorimeter with Appliances for the Direct Determination of Oxygen. Octavo, 193 pages, 49 figures. Published 1905. Price $1.25.

A technical description of an apparatus for use in experiments with man, permitting the simultaneous determination of carbon dioxide, water-vapor, heat elimination, and oxygen absorption. The respiration apparatus is of the closed-circuit type of Regnault and Reiset, the unique feature of which is the accurate determination of oxygen. The calorimeter is of the continuous-flow type, provided with arrangements for keeping the walls adiabatic. The apparatus was developed and constructed in the Chemical Laboratory of Wesleyan University, where it was in use for a number of years, and many experiments on man were made with it. One such experiment is described in this report.

No. 77. BENEDICT, F. G. The Influence of Inanition on Metabolism. Octavo, VII+542 pages, 2 text figures. Published 1907. Price $2.75.

An extended investigation by means of the respiration calorimeter on the influence of varying degrees of inanition upon metabolism. Fourteen experiments were made with 10 different individuals and the fasting period extended from 2 to 7 days, during which time the subject was inside the respiration chamber. The complete metabolism was studied and the discussion includes an extended consideration of the influence of inanition on body-weights, temperature, pulse, respiration, blood, strength, feces, urine, water excretion, carbon-dioxide elimination, oxygen consumption, and the transformation of energy. Two nitrogen metabolism experiments throw considerable light upon recuperation after fasting.

No. 123. BENEDICT, FRANCIS G., and T. M. CARPENTER. Respiration Calorimeters for Studying the Respiratory Exchange and Energy Transformations of Man. Octavo, vII+102 pages, 32 figs. Published 1910. Price $0.75. In the two calorimeters, one of them for bed-ridden patients, the heat eliminated by man is measured by a current of cold water passing through a heat-absorbing system inside the chamber, the mass of water and the temperature rise being known. Direct measurement of the water vaporized gives the latent heat of water-vapor. By means of a system of thermal junctions, any slight temperature differences between the inner copper wall and an outer zinc wall are constantly noted. The temperature of the zinc wall is arbitrarily adjusted by heating and cooling to maintain it at the temperature of the copper wall, thus holding the calorimeter in an adiabatic condition. The chambers are large enough for a man to remain comfortably seated or lying for several hours, an electric light furnishes illumination, connection is made by call-bell and telephone with the outside, and a supply of air is continually circulated through the chamber, and thence through weighed vessels containing sulphuric acid and soda lime to absorb quantitatively water-vapor and carbon dioxide. The oxygen consumed is determined by admitting the gas from a weighed cylinder of highly compressed pure oxygen. Analyses of the air residual in the chamber are made at the end of every period, and corrections for barometric changes are applied. Electrical resistance thermometers are used to measure calorimeter as well as body temperatures. A stethoscope and pneumograph permit the measurement of the pulse-rate and respiration-rate. A graphic record of the minor muscular movements is also furnished by the tracing of the pneumograph tambour. The apparatus has been most carefully checked as a calorimeter by the development of the heat from a known electrical current inside the chamber, and the accuracy of measurement of all four factors-carbon dioxide, water-vapor, oxygen absorption, and heat production-has been controlled by burning known weights of pure ethyl alcohol. The methods of calculation and the details of the routine of an experiment with man are included.

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