or less accumulation of pigment in the splenic pulp. 2d. Pigmentary deposits in different tissues, especially in those which are in closest contact with the blood circulating within the walls of the vessels. The deposits are found in greater frequency and abundance in the meshes of the minute capillaries in which the dark colored granules are subjected to prolonged stasis by reason of the obstruction to the circulation which they themselves occasion.

The pigment thus deposited in the vascular and perivascular tissues is quite as dark as that which is found in the blood and in the spleen; even among those which a pernicious attack has removed from the beginning of the poisoning, the pigmentation of the hepatic and cerebral capillaries is as deep as the pigmentation of the blood. I now no longer believe that the dark colored deposits made around and within the meshes of the vessels in malarial poisoning are the result of the transformation, in place, of the coloring matter of the red blood corpuscles. these deposits were the product of such a transformation there would be found, especially among the individuals named, from the commencement of the poisoning intermediate degrees of coloration between the red tint of extravasated blood and the melanotic tint; but these degrees are not found to exist.

If

The migration of pigmentary granules contained in the blood current seems then to be the origin of the pigmentation of the walls of the vessels. But does this migration take place by simple penetration of the granules without a vehicle of any sort ?

There exists, in our opinion, active intermediate agents to assist in this migration; these are the leucocytes which seize upon and envelope, so to speak, the foreign bodies with which they come in contact, and by virtue of their amoeboid movements are able to traverse the walls of the minute capillaries and diffuse themselves through the tissues. This double character of leucocytes has even been utilized to inject coloring substances into the blood of animals, and to prove more clearly in local inflammations the migration of these globules through the vascular walls

where they carry with them the colored corpuscles which they have enclosed and which reveal their passage. That which causes me to admit the agency of leucocytes in this extravasation of melanotic pigment is that in the blood itself the pigmentary granules are the more habitually enclosed either in leucocytes that are clearly recognized as such or in a hyaline substance which constitutes a transparent zone about them and appears to us to indicate that here also the envelope is a white corpuscle modified more or less in form.

It was this arrangement that I indicated in a recent communication made to the Medical Society of the hospitals, in reference to a fatal illness that occurred in my practice, and of which I made the autopsy in company with M. Kelsch. Leucocytes, therefore, containing pigment traverse the walls of the vessels, and since they themselves after their passage disappear in the meshes of the tissues in order to engage in the various nutritive processes, they deposit in the substance of the tissues and exterior to the vessels the pigmentary material with which they become impregnated while in the blood.

Since I made my first communication to the Academy of Sciences upon malarial poisoning, the doctrine of the migration of leucocytes charged with melanotic pigment has received the additional confirmation of several different observers :-Ist. The Treatise on Pathological Histology, edited by M. M. Cornil and Ranvier concerning the lesions found as the result of pernicious fevers, contains the following:

"In the cases that we have observed the pigmentary particles which exist in the blood are round or angular, of an intense blackness, varying in diameter from extreme minuteness to the 8 or 9 thousandth of a millimetre; they are all contained in white globules or enveloped by a colorless, granular zone, which very probably represents the protoplaem of a white cor. puscle forming a thin film around the pigmentary granule.

"When the patient succumbs and the autopsy is made most of the organs, but especially the spleen and the liver are

found of a slatey gray color. Upon making incisions in the organs after hardening with alcohol pigmentary granules are found in the white corpuscles contained in the vessels, in the vascular cells and in the cells of the parenchyma. The visceral lymphatic ganglia are likewise pigmented.

"The pathological pigment deports itself here in the same manner as any inert granular matter contained in the bloodVermillion for example.

Where finely powdered vermillion suspended in water is injected into the blood of an animal the granules are taken up by the white corpuscles and carried by them into the various organs; they traverse the vascular walls and so dispose themselves finally in those structures which are the seat of the pathological pigmentation. It is correct to suppose that melanemic proves conclusively the pigmentary transportation of the blood in the spleen, and the transformation of the pigment in the blood by the white corpuscles.

(To be Continued.)

SALICYLIC ACID AS AN ANTIPYRETIC.

Dr. Hiller in Deutsches Archiv fur Klinischi Medizin, after comparing the respective advantages and disadvantages of quinine and salicylic as antipyretics, concludes as follows:Salicylic acid is certainly an antipyretic, but, with reference to its exhibition and working, by no means competing with quinine, and no one can doubt that its lot with the last named will not be equal.

After all, who, in spite of himself, is not forced to recall to memory the old quarrel between Cortex Salicis and Cortex China-Audi Alteram Partem.

SALICYLIC ACID FOR FOUL BREATH AND OFFENSIVE EXPECTORATION.

Prof. DaCosta recommends Salicylic acid as an agreeable and harmless remedy against foul breath, and claims also that it acts

as a detergent on the character of offensive secretions. In a case of gangrene of the lungs the administration of this agent was followed by a marked improvement in all the disagreeable symptoms.

If the internal administration should fail to accomplish the desired result the remedy may be used in the atomizer in a solution of ten grains to the ounce of water, with enough glycerine to render it soluble. Dr. DaCosta has employed it a number of times with marked success in cases of indigestion with bad breath.

By itself Salicylic acid is practically insoluble in water, but the addition of a small quantity of borax will enable ten grams to be taken np by an ounce of water. In this form it has been used in the Pennsylvania Hospital as a mouth wash, and gargle, with much satisfaction:

HIGH TEMPERATURE.-Mr. J. W. Teale read at a meeting of the Clinical Society of London, Eng., notes of a case in which the temperature as shown by the thermometer was unusally high. The patient, a young lady was thrown in the hunting field, on Sept. 5th, 1874, by her horse taking a standing jump at a five barred gate, and catching his feet in the topmost bar, pulling heavily upon the rider. The lady staggered to her feet after momentary unconsciousness, and was seen in five or six hours after by Dr. Teale. She was in a state of collapse and complained of pain in the back. The left fifth and sixth ribs were fractured, but united kindly. There was some considerable pain and tenderness in the back, and the temperature remained from

normal to 101° Fah. for some time. On Nov. 3d it was 105° Fah.; on the 4th 106° Fah.; Nov. 8th 110° Fah.; Nov. 11th 116°; Nov. 12th it fell to 110° Fah.; Nov. 13th, 122° Fah.; the utmost limit of the thermometer used. The range of temperature varied very greatly, and no less than seven different thermometers were used to guard against error, but they all registered the same. As the Clinical thermometers registered only 118°, Mr. Teale had one of 122° made for this case, but it was not sufficient. He thinks the temperature probably rose to 125°. The patient recovered.-(Lancet.)

SALIVATION DURING GESTATION.-W H. Gatewood, Jamaica, Va., reports a care of salivation during gestation, to the amount of three to four quarts of spittle per day during the entire time. The flow of saliva decreased after delivery but it had not entirely ceased. This woman, a primipora, was trouled with severe after-pains and" Phlegmasia Dolens of both upper extremities." The phlegmasea was treated with hot hop fomentations with very satisfactory results.- Va. Med. Monthly.

HYPODERMIC INJECTION OF MORPHIA.-Dr. W. A. Greene of Ameneus, Ga., states that he knows a man who had used hypodermic injections of morphine, on an averge of six times a day for the last four and a half years, with at least two grains at each dose. This man has used to Sept. 1st, 1875, fully 1,500 injections and 3500 of the salt. These injections were made by himself and others not familiar with the process, and little or no attempt made to avoid the injection of air. "I am sure the young man, from first to last, has had pounds of atmospheric air in his [injections], and without the least unpleasant effects." "He has not had during all this time exceeded half a dozen abscesses from the use of the syringe."-Richmond and Louisville Med. Journal, Jan. 1876.